Respiratory Complications Following Pediatric Liver Transplantation: Frequency, Risk Factors, and Clinical Predictors of Chronic Morbidity


Unal F., Saka B., Ayman F. N., TELHAN L., SEVMİŞ Ş., DAYANGAÇ M., ...Daha Fazla

Transplantation Proceedings, cilt.58, sa.4, ss.755-759, 2026 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 58 Sayı: 4
  • Basım Tarihi: 2026
  • Doi Numarası: 10.1016/j.transproceed.2026.03.022
  • Dergi Adı: Transplantation Proceedings
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE
  • Sayfa Sayıları: ss.755-759
  • İstanbul Yeni Yüzyıl Üniversitesi Adresli: Evet

Özet

Objective: To investigate the incidence, characteristics, and risk factors of postoperative respiratory complications in pediatric liver transplant (LT) recipients, and to identify clinical predictors of chronic respiratory morbidity. Methods: We retrospectively analyzed data from 42 pediatric patients who underwent LT between 2014 and 2020. Variables assessed included demographics, primary liver disease, pre-transplant comorbidities, perioperative factors, and postoperative respiratory complications (PTRCs). Complications were categorized as early or chronic (persisting >3 months). Statistical associations between complications and clinical features were evaluated. Results: Postoperative respiratory complications occurred in 67% of patients, with pleural effusion (45%), pneumonia (33%), and postextubation respiratory failure (33%) being most common. Chronic respiratory complications were observed in 14% of patients and were significantly associated with prior abdominal surgery, prolonged pediatric intensive care unit stay, and postextubation respiratory failure. Pre-transplant pneumonia, ascites, portal hypertension, and recurrent abdominal surgery were identified as significant risk factors for PTRCs. Pulmonary hemorrhage was the only complication associated with mortality. Conclusion: Respiratory complications are common in pediatric LT recipients and are strongly associated with pre-existing pulmonary and intra-abdominal conditions. Early recognition of at-risk patients may allow for improved perioperative strategies and long-term respiratory outcomes.