Simultaneous determination of acetaminophen and caffeine in tablet preparations by partial least-squares multivariate spectrophotometric calibration

Bozdoǧan A., ACAR A. M., KANDEMİR G.

Talanta, cilt.39, sa.8, ss.977-979, 1992 (Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 8
  • Basım Tarihi: 1992
  • Doi Numarası: 10.1016/0039-9140(92)80281-h
  • Dergi Adı: Talanta
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.977-979
  • İstanbul Yeni Yüzyıl Üniversitesi Adresli: Evet

Özet

The use of partial least-squares spectrophotometric calibration for the simultaneous determination of analgesic tablets in a multicomponent formulation is presented. This method is applied to the determination of acetaminophen and caffeine in tablet preparations. The results show that these components in a molar ratio of about 21:1 in tablets have been determined simultaneously with high precision. © 1992.