Serum Anti-müllerian hormone, follicle stimulating hormone and antral follicle count measurement cannot predict pregnancy rates in IVF/ICSI cycles

Sahmay S., Demirayak G., Guralp O., ÖÇAL K. P., Senturk L. M., Oral E., ...Daha Fazla

Journal of Assisted Reproduction and Genetics, cilt.29, sa.7, ss.589-595, 2012 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 7
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1007/s10815-012-9754-6
  • Dergi Adı: Journal of Assisted Reproduction and Genetics
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.589-595
  • Anahtar Kelimeler: Antimüllerian hormone, Antral follicle count, Clinical pregnancy rate, Follicle stimulating hormone
  • İstanbul Yeni Yüzyıl Üniversitesi Adresli: Evet

Özet

Purpose To investigate whether serum anti-müllerian hormone (AMH), follicle stimulating hormone (FSH), or antral follicle count (AFC) are predictive for clinical pregnancy in in vitro fertilization (IVF) patients. Methods Serum AMH, inhibin B, FSH, luteinizing hormone (LH), estradiol (E2), prolactin, and thyroid stimulating hormone (TSH) levels and AFC of 189 women under 40 years of age were investigated. Pregnant and nonpregnant women were compared. Results Forty-seven (24.8%) clinical pregnancies were observed in 189 women. There was no significant difference in terms of mean age, duration of infertility, body mass index, AMH, LH, FSH, E2, TSH, Inhibin B, AFC and total oocyte number between women who did and who did not become pregnant. Additionally, there was no significant difference in clinical pregnancy rates between the quartiles of AMH, FSH and AFC. (P values were 0.668, 0.071, and 0.252, respectively.) Conclusion Serum AMH and FSH, and AFC cannot predict clinical pregnancy in IVF patients under 40; the pregnancy rate tends to increase asAMHincreases, although this remains non-significant. © 2012 Springer Science+Business Media, LLC.