Obbjjeeccttiivvee:: Our aim in this study is to assess the rate and possible causes of nonpersis- tence among patients with diabetes who have received standard insulin education for their in- sulin treatment. MMaatteerriiaall aanndd MMeetthhooddss:: 700 patients with type II diabetes, who were started on insulin treatment by outpatient clinics of Dr. Lütfi Kırdar Kartal Training and Research Hospital between 1/1/2012-1/1/2013, and who had received the same standard insulin education given by diabetes nurses, were enrolled in this study. Patients were called by the phone and a questionnaire was filled regarding patients' socio-demographic characteristics, comorbidities and patients' in- sulin use. We have reached 462 patients/relatives. Total of 14 patients died, and 23 patients, whose insulin treatment was nonpersistent by a physician, were excluded. 425 patients were included in the final analysis. RReessuullttss:: Among 425 patients, 50.8% were male, mean age was 57.7 years (±11.6 years) and average time since diabetes diagnosis was 6.6 years (±6.2 years). 57.6% were on basal, 17.9% on premixed and 24.5% were on basal-bolus insulin regimen. The rate of nonpersis- tence was found to be 6.2%. Non-parametric correlation tests revealed that compliance rates sig- nificantly increased with increased age (p=0.01, r=0.12). Most common causes of nonpersistence were hypoglycemia, fatigue (26.9%), feeling good and cured (23%) and difficulties in injections (15.3%) allergy 11.5%, environmental factors 7.6%, and fear of addiction 7.6%. CCoonncclluussiioonnss:: De- tecting the underlying causes of nonpersistence of insulin by the healthcare centers that initiated the treatment, and utilizing these data for revising standard insulin education programs could be a key factor for reaching the desired glycemic goals in patients with diabetes.