Healthcare-associated Gram-negative bloodstream infections: antibiotic resistance and predictors of mortality

Ergönül, Ö.; Aydin, M.; Azap, A.; Başaran, S.; Tekin, S.; Kaya, Ş.; Gülsün, S.; Yörük, G.; Kurşun, E.; Yeşilkaya, A.; Şimşek, F.; Yılmaz, E.; Bilgin, H.; Hatipoğlu, Ç.; Cabadak, H.; Tezer, Y.; Togan, T.; Karaoğlan, İ.; İnan, A.; ENGİN, AYNUR; Alışkan, H.E.; Yavuz, S.Ş.; Erdinç, Ş.; Mulazimoglu, L.; Azap, Ö.; Can, F.; Akalın, H.; Timurkaynak, F.

doi:10.1016/j.jhin.2016.08.012

Healthcare-associated Gram-negative bloodstream infections: antibiotic resistance and predictors of mortality

Ergönül Ö., Aydin M., Azap A., Başaran S., Tekin S., Kaya Ş., ...Daha Fazla

Journal of Hospital Infection, cilt.94, sa.4, ss.381-385, 2016 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 94 Sayı: 4
Basım Tarihi: 2016
Doi Numarası: 10.1016/j.jhin.2016.08.012
Dergi Adı: Journal of Hospital Infection
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.381-385
Anahtar Kelimeler: Bloodstream, Gram-negative, Healthcare
İstanbul Yeni Yüzyıl Üniversitesi Adresli: Hayır

Özet

This article describes the prevalence of antibiotic resistance and predictors of mortality for healthcare-associated (HA) Gram-negative bloodstream infections (GN-BSI). In total, 831 cases of HA GN-BSI from 17 intensive care units in different centres in Turkey were included; the all-cause mortality rate was 44%. Carbapenem resistance in Klebsiella pneumoniae was 38%, and the colistin resistance rate was 6%. Multi-variate analysis showed that age >70 years [odds ratio (OR) 2, 95% confidence interval (CI) 1.22–3.51], central venous catheter use (OR 2.1, 95% CI 1.09–4.07), ventilator-associated pneumonia (OR 1.9, 95% CI 1.1–3.16), carbapenem resistance (OR 1.8, 95% CI 1.11–2.95) and APACHE II score (OR 1.1, 95% CI 1.07–1.13) were significantly associated with mortality.