Prevalence of MMP-3 E45K polymorphism in Turkish patients with endometrial carcinoma
Medicine Science, vol.7, no.4, pp.762-765, 2018 (TRDizin)
- Publication Type: Article / Article
- Volume: 7 Issue: 4
- Publication Date: 2018
- Doi Number: 10.5455/medscience.2018.07.8870
- Journal Name: Medicine Science
- Journal Indexes: TR DİZİN (ULAKBİM)
- Page Numbers: pp.762-765
- İstanbul Yeni Yüzyıl University Affiliated: No
Abstract
Endometrial carcinoma is a metastatic and recurrent disease has a worse prognosis. We aim to investigate the MMP-3 gene polymorphism in Turkish patients with endometrial carcinoma. In recent years, number of genetic studies have been increased to find new prognostic and theraupeutic markers. Matrix metalloproteinases [MMPs] are proteolytic enzymes that degrade all components of the extracellular matrix which are play an important role of cancer metastasis and invasion. MMP-3, also known as stromelysin-1, to lyse basal membrane collagen and induce the synthesis of some other MMPs. 97 patients with endometrial carcinoma and 100 healthy controls were included in this study. MMP-3 E45K polymorphism was determined using polymerase chain reaction/ restriction fragment length polymorphism in study groups. There were no significant differences between any genotypes or allele in control and patient groups for MMP-3 E45K polymorphism. Besides no significant correlation was found between MMP-3 E45K polymorphisms and clinical characteristics, such as histology, grade, metastasis and family history. ur study suggests that the MMP-3 E45K polymorphism is not associated with endometrial carcinoma process in Turkish patients.