What to advise to patients with only one good quality blastocyst, PGT-A or not? Outcomes of 2064 cycles

Kahraman S., Duzguner I. N. B., Sahin Y., İREZ T.

Journal of Assisted Reproduction and Genetics, cilt.39, sa.11, ss.2555-2562, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 39 Sayı: 11
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1007/s10815-022-02617-7
  • Dergi Adı: Journal of Assisted Reproduction and Genetics
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, ATLA Religion Database, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.2555-2562
  • Anahtar Kelimeler: Clinical pregnancy, Live birth, PGT-A, Single blastocyst
  • İstanbul Yeni Yüzyıl Üniversitesi Adresli: Evet

Özet

Purpose: To evaluate whether preimplantation genetic testing for aneuploidy (PGT-A) is beneficial for patients who have only one blastocyst available for biopsy or transfer. Methods: This retrospective study was based on 1126 single blastocyst PGT-A and 938 non-PGT-A cycles, a total of 2064 ART cycles which resulted in a single good quality blastocyst in women between 20 and 45 years old. The PGT-A group had 225 single euploid embryo transfer cycles and the non-PGT-A group had 938 single blastocyst embryo transfer cycles. Results: In the generalized linear mixed model (GLMM), female age and PGT-A variables were found to be significant variables on pregnancy outcomes. In the PGT-A cases, regardless of the effect of other variables, the probabilities of clinical pregnancy and live birth were found to be 3.907 and 3.448 fold higher respectively than in the non-PGT-A cases (p < 0.001). In non PGT-A cases, the probability of a total pregnancy loss was found to be 1.943 fold higher (p = 0.013). Conclusion: PGT-A in the presence of a single blastocyst significantly increases clinical pregnancy and live birth rates and decreases total pregnancy losses regardless of age. In addition, aneuploid embryo transfer cancelations prevent ineffective and potentially risky transfers.