The effect of hyaluronic acide carboxymethyl cellulosis on the healing of colonic anastomosis in rats

Adas G., Karatepe O., Arýkan S., Battal M., Kemik O., Altiok M., ...Daha Fazla

Bratislava Medical Journal, cilt.110, sa.4, ss.210-214, 2009 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 110 Sayı: 4
  • Basım Tarihi: 2009
  • Dergi Adı: Bratislava Medical Journal
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.210-214
  • Anahtar Kelimeler: Colon anastomosis, Hyaluronic acide carboxymethyl cellulozis, Wound healing
  • İstanbul Yeni Yüzyıl Üniversitesi Adresli: Hayır

Özet

Background: This study demonstrates the effect of hyaluronic acid-carboxymethylcellulose on the healing of colonic anastomosis. Method: 30 female Wistar-Albino rats were divided into three groups; control group 1 (n = 10), treated with hyaluronic acid-carboxymethylcellulose, group 2 (n=8) treated with HBO and group 3 with hyaluronic acid-carboxymethylcellulose and HBO. Result: Bursting pressure and rupture strength were significantly higher in the group 3 compared to other two groups (p<0.05). The severity of necrosis, granulation, neovascularisation and epithelization among groups did not show any significant difference (p>0.05). But the evaluation of inflammation showed a statistical significance (p<0.001) such as as granulation (p<0.05). Conclusion: This study did not detect the negative affect of seprafilm on wound healing. Combined treatment with seprafilm and HBO has a favorable therapeutic effect on the healing of ischemic colonic anastomosis.