The effect of hyaluronic acide carboxymethyl cellulosis on the healing of colonic anastomosis in rats
Bratislava Medical Journal, cilt.110, sa.4, ss.210-214, 2009 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 110 Sayı: 4
- Basım Tarihi: 2009
- Dergi Adı: Bratislava Medical Journal
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.210-214
- Anahtar Kelimeler: Colon anastomosis, Hyaluronic acide carboxymethyl cellulozis, Wound healing
- İstanbul Yeni Yüzyıl Üniversitesi Adresli: Hayır
Özet
Background: This study demonstrates the effect of hyaluronic acid-carboxymethylcellulose on the healing of colonic anastomosis. Method: 30 female Wistar-Albino rats were divided into three groups; control group 1 (n = 10), treated with hyaluronic acid-carboxymethylcellulose, group 2 (n=8) treated with HBO and group 3 with hyaluronic acid-carboxymethylcellulose and HBO. Result: Bursting pressure and rupture strength were significantly higher in the group 3 compared to other two groups (p<0.05). The severity of necrosis, granulation, neovascularisation and epithelization among groups did not show any significant difference (p>0.05). But the evaluation of inflammation showed a statistical significance (p<0.001) such as as granulation (p<0.05). Conclusion: This study did not detect the negative affect of seprafilm on wound healing. Combined treatment with seprafilm and HBO has a favorable therapeutic effect on the healing of ischemic colonic anastomosis.