Prolactin, growth hormone and the immune system in humans

Velkeniers B., Dogusan Z. D., Naessens F., Hooghe R., Hooghe-Peters E.

Cellular and Molecular Life Sciences, cilt.54, sa.10, ss.1102-1108, 1998 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 54 Sayı: 10
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1007/s000180050239
  • Dergi Adı: Cellular and Molecular Life Sciences
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1102-1108
  • Anahtar Kelimeler: Acromegaly, Ageing, AIDS, Growth hormone, Insulin-like growth factor, Pituitary adenoma, Prolactin
  • İstanbul Yeni Yüzyıl Üniversitesi Adresli: Hayır

Özet

Prolactin (PRL) and growth hormone (GH) qualify as lymphoid growth and differentiation factors. Yet, long-standing hyper- or hyposecretion of PRL or GH does not induce any significant alteration of the immune system. Subclinical changes in laboratory parameters (such as chemotaxis or phagocytosis by granulocytes or macrophages or natural killer cell activity) have been reported in some of these conditions. The GH-insulin-like growth factor (IGF)-I axis is dysregulated in ageing, in catabolic states and in critical illness. Immune parameters, such as infection rate, are being monitored during clinical trials with GH or IGF-I. Hyperprolactinaemia may play an aggravating role in systemic lupus erythematosus, in autoimmune thyroiditis and in other autoimmune diseases. The patient may benefit from increased alertness about interactions between the endocrine and immune systems.