Determination of the biological activities of endemic Allium lazikkiyense and its phytochemical profile by LC-MS/MS analysis

Hasbal-Celikok G., Azami F. T., ÇELİKOK Y., Duranay S., Kocyigit M., Yilmaz-Ozden T.

Food Chemistry, cilt.464, 2025 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 464
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1016/j.foodchem.2024.141930
  • Dergi Adı: Food Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aerospace Database, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, EMBASE, Food Science & Technology Abstracts, Metadex, Veterinary Science Database, Civil Engineering Abstracts
  • Anahtar Kelimeler: Allium lazikkiyense, Anticancer, Antioxidant, Enzyme inhibitory
  • İstanbul Yeni Yüzyıl Üniversitesi Adresli: Evet

Özet

This study investigated the phytochemical contents and in vitro antioxidant, enzyme inhibitory and anticancer properties of ethanol, methanol, and dichloromethane extracts prepared from aerial parts and onion peels of endemic Allium lazikkiyense Koçyiğit, Özhatay & E.Kaya. Ethanol extracts showed the highest antioxidant activity among the all extracts in terms of total phenolic and flavonoid contents as well as DPPH scavenging and iron reducing potentials. LC-MS/MS analysis results showed that aerial parts rich in fumaric acid, p-coumaric acid, ascorbic acid and hyperoside while onion peels rich in sarsasapogenin, caffeic acid and fumaric acid. Dichloromethane extracts showed a strong inhibitory effect on α-glucosidase, while all extracts exhibited low inhibitory activity on α-amylase, acetylcholinesterase and butyrylcholinesterase. Also, extracts from onion peels exhibited potent cytotoxic effect against MCF7 human breast cancer cells. The present study revealed that A. lazikkiyense could be a good natural source for antioxidant, α-glucosidase inhibitory, and anticancer activities.