Assessment of lipid profile and some risk factors of atherosclerosis in children whose parents had early onset coronary artery disease

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Bornaun H., Öner N., Nisli K., Öztarhan K., Yavuz T., Türkoglu Ü., ...Daha Fazla

Archivos Argentinos de Pediatria, cilt.115, sa.1, ss.50-53, 2017 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 115 Sayı: 1
  • Basım Tarihi: 2017
  • Doi Numarası: 10.5546/aap.2017.eng.50
  • Dergi Adı: Archivos Argentinos de Pediatria
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.50-53
  • Anahtar Kelimeler: Children, Coronary artery disease, Lipids, Offspring, Risk factors
  • İstanbul Yeni Yüzyıl Üniversitesi Adresli: Evet

Özet

Background/Aim: The objective of our study was to analyze the lipid profile and some risk factors of atherosclerosis such as oxidized-low density lipoprotein (ox-LDL), small dense LDL (sd LDL) in the offspring of patients with premature coronary heart disease (CHD). Population and Methods: Children whose parents had early onset CHD were matched with age and sex pairs. Study and controls were analyzed for lipid levels, apolipoproteins (Apo- A,B,E), ox-LDL, sd LDL and lipoprotein (a) [Lp(a)]. The data were evaluated with SPSS using "Student t and Mann-Whitney U" tests. Results: The study group children (n: 43) had higher LDL, Lp(a) and ox-LDL levels, ratios of TC/HDL, Apo-B/A, LDL/HDL and ox-LDL/HDL (p<0.05) than control group. Conclusion: These findings suggest that dyslipidemia and increased LDL, Lp(a) and ox-LDL levels are common in the offspring of patients with early onset CHD and account largely for their familial predisposition for CHD.