Assessment of lipid profile and some risk factors of atherosclerosis in children whose parents had early onset coronary artery disease

Creative Commons License

Bornaun H., Öner N., Nisli K., Öztarhan K., Yavuz T., Türkoglu Ü., ...More

Archivos Argentinos de Pediatria, vol.115, no.1, pp.50-53, 2017 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 115 Issue: 1
  • Publication Date: 2017
  • Doi Number: 10.5546/aap.2017.eng.50
  • Journal Name: Archivos Argentinos de Pediatria
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.50-53
  • Keywords: Children, Coronary artery disease, Lipids, Offspring, Risk factors
  • İstanbul Yeni Yüzyıl University Affiliated: Yes

Abstract

Background/Aim: The objective of our study was to analyze the lipid profile and some risk factors of atherosclerosis such as oxidized-low density lipoprotein (ox-LDL), small dense LDL (sd LDL) in the offspring of patients with premature coronary heart disease (CHD). Population and Methods: Children whose parents had early onset CHD were matched with age and sex pairs. Study and controls were analyzed for lipid levels, apolipoproteins (Apo- A,B,E), ox-LDL, sd LDL and lipoprotein (a) [Lp(a)]. The data were evaluated with SPSS using "Student t and Mann-Whitney U" tests. Results: The study group children (n: 43) had higher LDL, Lp(a) and ox-LDL levels, ratios of TC/HDL, Apo-B/A, LDL/HDL and ox-LDL/HDL (p<0.05) than control group. Conclusion: These findings suggest that dyslipidemia and increased LDL, Lp(a) and ox-LDL levels are common in the offspring of patients with early onset CHD and account largely for their familial predisposition for CHD.