Pediatric inhalation risk assessment of Homosalate-containing spray sunscreens

Yazar Ürek S., Sarıgöl Kılıç Z.

12th International Congress of the Turkish Society of Toxicology’, İstanbul, Turkey, 6 - 09 November 2025, (Full Text)

  • Publication Type: Conference Paper / Full Text
  • City: İstanbul
  • Country: Turkey
  • İstanbul Yeni Yüzyıl University Affiliated: Yes

Abstract

Organic UV filters have become an integral part of human lifestyle due to their ability to block harmful UV radiation through topical application. In addition to their widespread use in cosmetics and personal care products such as anti-aging creams, lipsticks, hair conditioners, body lotions, hair dyes, and shampoos, these heterogeneous organic chemicals are also employed in textiles, plastic coatings, and paint products to prevent photodegradation and discoloration.

Homosalate (HMS) is one of the most commonly used UV-B filters in sunscreens marketed for the pediatric population. Although some studies have reported endocrine-related effects, evidence regarding potential health risks in humans remains limited. Spray formulations represent the primary route of HMS exposure via inhalation among consumers. However, data on this exposure pathway in pediatric populations are insufficient, and a comprehensive assessment of inhalation risks in children has not yet been conducted.

In this study, the effects of daily usage frequency of sunscreen spray formulations containing HMS were evaluated in children aged 6–11 years. For risk assessment, systemic exposure calculations were performed under different usage scenarios (once, twice, and six times per day), and Margin of Safety (MOS) values for HMS were determined using the ConsExpo 1.2.0 program.

In conclusion, it was determined that an increase in the daily usage frequency of sunscreen spray products containing Homosalate leads to higher systemic exposure, and that long-term use of these products may pose potential health risks. The risk may be further elevated in individuals with allergic respiratory diseases. These findings indicate that caution should be exercised in the long-term use of such products in children, as safety thresholds may be exceeded.

Keywords: UV filters; homosalate; risk assessment; children; inhalation; sunscreen