Serum apelin-13 levels and total oxidant/antioxidant status of patients with Alzheimer’s disease

Yildiz Z., EREN N., Orcun A., Münevver Gokyigit F., Turgay F., Gündogdu Celebi L.

Aging Medicine, vol.4, no.3, pp.201-205, 2021 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 4 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.1002/agm2.12173
  • Journal Name: Aging Medicine
  • Journal Indexes: Scopus
  • Page Numbers: pp.201-205
  • Keywords: Alzheimer’s disease AD), apelin, In this study, oxidative stress, total antioxidant status (TAS), total oxidant status (TOS), we aimed to investigate apelin-13 levels in AD and their relation with total antioxidant status (TAS) and total oxidant status (TOS).
  • İstanbul Yeni Yüzyıl University Affiliated: Yes

Abstract

Objective: We aimed to evaluate apelin-13 levels, total oxidant/antioxidant status in Alzheimer’s disease (AD) and to investigate the relationship between these parameters. Methods: Patients newly diagnosed with AD were enrolled in the study. The control group consisted of age- and gender-matched healthy individuals. Serum levels of apelin-13, total antioxidant status (TAS), and total oxidant status (TOS) were measured. Oxidative stress index was calculated (TOS/TAS) for each participant. Results: We reported that serum apelin-13 and TAS values were significantly lower in the AD group compared with controls, and they found a fair but insignificant relationship between Apelin-13 and TAS values. Conclusion: According to our results, we suggested that insufficient apelin-13 and TAS levels may contribute to the pathogenesis of AD.