Cumulative urinary excretion of some ciprofloxacin tablets in healthy volunteers

Ekinci A., BAKTIR G., Otuk G., ÖZDEMİR Ö., Sunam G., ÖZER H.

Scientia Pharmaceutica, cilt.62, sa.3, ss.247-253, 1994 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 62 Sayı: 3
  • Basım Tarihi: 1994
  • Dergi Adı: Scientia Pharmaceutica
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.247-253
  • Anahtar Kelimeler: ciprofloxacin, relative bioavailability, urinary excretion
  • İstanbul Yeni Yüzyıl Üniversitesi Adresli: Evet

Özet

The bioavailability of two brands of ciprofloxacin tablets (B and C) marketed in Turkey was compared to that of ciprofloxacin tablet (A) using cumulative urinary data. All brands were administered to seven healthy subjects in Latin Square design as a single oral dose of 500 mg and the 24-hour cumulative amount of ciprofloxacin excreted in urine was measured using agar plate diffusion antibiotic assay. The percentage urinary excretion for brands A, B and C were 28.5 ± 7.9 (x̄ ± SD), 21.2 ± 7.9 and 20.4 ± 6.8% of the dose administered, respectively. It seems that the difference was neither statistically significant nor a disadvantage from the therapeutic point of view. But interindividual variation should be elucidated as an important factor for efficient therapy.