Comparison of Alternative Lipid Emulsions on Morbidities in Very-Low-Birth-Weight Preterms


Zübarioğlu A. U., Dursun M.

Indian Journal of Pediatrics, cilt.88, sa.9, ss.905-911, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 88 Sayı: 9
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1007/s12098-021-03691-y
  • Dergi Adı: Indian Journal of Pediatrics
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, BIOSIS, CINAHL, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.905-911
  • Anahtar Kelimeler: Fish oil, Morbidity, Olive oil, Preterm, Total parenteral nutrition
  • İstanbul Yeni Yüzyıl Üniversitesi Adresli: Evet

Özet

Objective: To compare clinical outcomes of using different alternative lipid emulsions for longer durations in babies who are at high risk for preterm morbidities. Methods: Preterm infants born ≤ 30 wk receiving SMOFlipid versus Clinoleic with longer durations (≥ 14 d) were included in this retrospective study. The authors compared demographic features, clinical applications, and morbidities between epochs: epoch 1 (Clinoleic, July 2017–June 2018) versus epoch 2 (SMOFlipid, July 2018–June 2019). Results: A total of 91 infants were included in the study. In bivariate analysis; moderate bronchopulmonary dysplasia (BPD) (p = 0.000) and composite outcome [BPD, retinopathy of prematurity (ROP) needed treatment, cholestasis and late-onset sepsis and/or mortality] rates were significantly higher (p = 0.043) in Clinoleic group. In multivariate logistic regression analysis, it was found that the type of lipid emulsion used had no significant effect on these morbidities. Conclusions: Since both groups had comparable morbidity and mortality, both lipid emulsions are equally safe in preterm babies requiring parenteral nutrition.