ADP-ribosylation of serum proteins: Elevated levels in neoplastic cases due to altered NAD/ADP-ribose metabolism

Albeniz I. Ü., Nurten R., Bermek E.

Cancer Investigation, vol.15, no.3, pp.217-223, 1997 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 3
  • Publication Date: 1997
  • Doi Number: 10.3109/07357909709039718
  • Journal Name: Cancer Investigation
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.217-223
  • Keywords: ADP-ribosylation, NAD glycohydrolase, Neoplastic disease, Serum NAD levels, Serum proteins
  • İstanbul Yeni Yüzyıl University Affiliated: No

Abstract

ADP-ribosylation of human serum proteins was studied in various groups of disorders. In most of these groups, the extent of ADP-ribosylation did not show a divergence from the group of normal controls. Neoplastic diseases revealed, however; a unique group, with more than fivefold increases in ADP- ribosylation levels over the other groups. Blood samples with high levels of ADP-ribosylation revealed, in general, increased serum NAD glycohydrolase activities and low levels of serum NAD.