ADP-ribosylation of serum proteins: Elevated levels in neoplastic cases due to altered NAD/ADP-ribose metabolism

Albeniz I. Ü., Nurten R., Bermek E.

Cancer Investigation, cilt.15, sa.3, ss.217-223, 1997 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 3
  • Basım Tarihi: 1997
  • Doi Numarası: 10.3109/07357909709039718
  • Dergi Adı: Cancer Investigation
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.217-223
  • Anahtar Kelimeler: ADP-ribosylation, NAD glycohydrolase, Neoplastic disease, Serum NAD levels, Serum proteins
  • İstanbul Yeni Yüzyıl Üniversitesi Adresli: Hayır

Özet

ADP-ribosylation of human serum proteins was studied in various groups of disorders. In most of these groups, the extent of ADP-ribosylation did not show a divergence from the group of normal controls. Neoplastic diseases revealed, however; a unique group, with more than fivefold increases in ADP- ribosylation levels over the other groups. Blood samples with high levels of ADP-ribosylation revealed, in general, increased serum NAD glycohydrolase activities and low levels of serum NAD.