Akademik Veri Yönetim Sistemi
Medical Science and Discovery, cilt.12, sa.6, ss.207-212, 2025 (Hakemli Dergi)
Objective: Rosacea is a chronic skin disorder of unknown etiology that primarily affects the central face. This study aimed to determine the prevalence of Helicobacter pylori (H. pylori) infection in patients with rosacea and to assess whether Helicobacter testing is warranted in this population.
Methods: This single-center retrospective study evaluated the prevalence of gastric H. pylori infection, confirmed via the rapid urease Campylobacter-like organism (CLO) test and the 13C-urea breath test, in patients with rosacea. Upper gastrointestinal endoscopy (UGIE) was performed in rosacea patients presenting with dyspepsia, and these individuals were tested for H. pylori. Those without dyspeptic symptoms underwent the 13C-urea breath test. Additionally, patients presenting solely with dyspepsia and undergoing UGIE in the Endoscopy Unit were assessed for H. pyloriinfection. The prevalence of H. pylori positivity was compared across groups to evaluate the necessity of testing rosacea patients for the infection.
Results: A total of 110 patients were diagnosed with rosacea by a dermatologist. Among them, H. pylori positivity was identified in 68 patients (61.8%). In a comparison group of 135 patients who underwent UGIE for dyspepsia alone, 70 (51.8%) tested positive for H. pylori. Subtype analysis revealed that the erythematotelangiectatic rosacea (ETR) subtype was more prevalent than papulopustular rosacea (PPR), and H. pylori positivity was significantly higher in the ETR group (p < 0.001).
Conclusion: Our findings indicate a notable association between H. pyloriinfection and rosacea, particularly within the erythematotelangiectatic subtype. Given the significantly higher prevalence of H. pylori in rosacea patients compared to those with dyspepsia alone, routine testing for H. pylori may be beneficial, especially in rosacea patients presenting with gastrointestinal symptoms. Identifying and treating H. pylori in this subgroup could potentially contribute to more effective management of rosacea. Future prospective studies are warranted to clarify the causal relationship and assess the therapeutic benefits of H. pylori eradication in rosacea treatment.