Akademik Veri Yönetim Sistemi
Zeitschrift fur Naturforschung - Section C Journal of Biosciences, 2025 (SCI-Expanded)
This study aims to investigate the chemical composition and assess the anti-cancer potential of Matricaria recutita L. essential oil against various cancer cell lines. The chemical profile of the essential oil was determined through gas chromatography-mass spectrometry (GC-MS), identifying major constituents such as (Z)-β-farnesene, α-bisabolol oxides, and chamazulene. The anti-cancer activity was evaluated using in vitro cytotoxicity assays (MTT assay) on human lung adenocarcinoma (A549), human hepatocellular carcinoma (HepG2), human breast adenocarcinoma (MDA-MB-231), and mouse fibroblast (L929) cell lines. The experiments were performed in triplicate, and data were analyzed using ANOVA to determine statistical significance. The main constituents of the essential oil included (Z)-β-farnesene (33.90 %), α-bisabolol oxide B (11.60 %), and others. The oil demonstrated considerable cytotoxic effects across all tested cancer cell lines, with IC50 values indicating strong anti-proliferative activity, particularly at higher concentrations and longer exposure times. The results showed dose-dependent reductions in cell viability, with significant decreases in cell proliferation observed especially at concentrations over 7.81 μg/mL. These findings support its potential as a natural, complementary agent in cancer therapy, warranting further in vivo studies for clinical application.