Akademik Veri Yönetim Sistemi
Istanbul Tip Fakultesi Dergisi, cilt.82, sa.1, ss.47-51, 2019 (Scopus)
Objective: Mice and rats fasted for 2 days and then treated with antimuscarinic drugs, scopolamine or atropine, develop convulsions soon after food intake. It has been demonstrated that deprivation of food for less than 48 h also causes convulsions in mice. Since there are differences in characteristics of the seizures between mice and rats, the present study evaluated whether rats also develop convulsions after being deprived of food for 3-24 h. Material and Method: Rats were deprived of food for 3, 6, 18, 24 and 52 h. At the time of testing, the animals were treated i.p. with saline or 3 mg/kg scopolamine and given food 20 min later. All animals were observed for 30 min, checking for the incidence and onset of convulsions. Results: The fasted animals treated with scopolamine developed convulsions after food intake. The incidence of convulsions was statistically significant in the 6, 18, 24 and 52 h deprived animals. However, neither the incidence nor the latency to seizures showed differences with respect to duration of food deprivation or fasting-induced weight loss. Conclusion: The present results demonstrate that the scopolamine treated rats that fasted for 24 h or less developed seizures after refeeding intake, indicating that food deprivation in itself, rather than its duration, seems to be the principal factor in the development of these convulsions.