Mitochondrial and microsomal lipid peroxidation in rat liver after acute acetaldehyde and ethanol intoxication

Uysal M., Özdemirler G., Kutalp G., Öz H.

Journal of Applied Toxicology, cilt.9, sa.3, ss.155-158, 1989 (Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 3
  • Basım Tarihi: 1989
  • Doi Numarası: 10.1002/jat.2550090304
  • Dergi Adı: Journal of Applied Toxicology
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.155-158
  • Anahtar Kelimeler: acetaldehyde, ethanol, lipid peroxidation, microsomes, mitochondria, rat liver
  • İstanbul Yeni Yüzyıl Üniversitesi Adresli: Hayır

Özet

The effects of acetaldehyde and ethanol treatments on hepatic lipid peroxidation are compared in rats after the administration of toxically corresponding doses. Wistar rats were given a single dose of acetaldehyde (0.5 g/kg) or ethanol (5 g/kg) intraperitoneally. The animals were killed 1/2, 1, 2, 4, 6, 9, 12 and 24 h after treatments. The results indicate that acetaldehyde, like ethanol, stimulates hepatic lipid peroxidation and also selectively affects the hepatic mitochondria. Copyright © 1989 John Wiley & Sons, Ltd.