Evaluation of rs781673405, rs1244378045, rs767450259, rs750556128, rs369143448, rs143353036, and rs759369504 mutations in terms of polymorphism in diabetic obese and non-diabetic obese individuals

AKSOYER SEZGİN S. B., Durak S., Celik F., GÜLER V., TOPAL SARIKAYA A., Zeybek U.

Endocrine, cilt.88, sa.2, ss.467-481, 2025 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 88 Sayı: 2
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1007/s12020-025-04184-0
  • Dergi Adı: Endocrine
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.467-481
  • Anahtar Kelimeler: Diabetes, Obesity, Polymorphism, TRAIL
  • İstanbul Yeni Yüzyıl Üniversitesi Adresli: Evet

Özet

Background: Obesity is among the important healthcare issues in which there is an abnormal increase in body fat because energy intake is higher than energy expenditure. The Tumor Necrosis Factor (TNF)-alpha overexpression in adipose tissue plays important roles in mediating obesity and insulin resistance. “TNF-related apoptosis-inducing Ligand (TRAIL(TNSF10))”, which is a member of the TNF family, is expressed as a Type-II Transmembrane Protein with an effect on the development of obesity and diabetes. Methods: The rs781673405, rs1244378045, rs767450259, rs750556128, rs369143448, rs143353036, and rs759369504 polymorphisms of TRAIL, which were determined to play protective roles against diabetes, were evaluated with the RT-qPZR Method in the present study. Results: It was found that the genotype distribution of TRAIL rs767450259 Polymorphism was significant and the T-Allele had protective effects against diabetic obesity. It was also found that the G-Allele of the rs369143448 Polymorphism had protective roles against diabetic obesity. It was shown that carrying the A-Allele in the rs750556128 Polymorphism might increase the risk of obesity in diabetic patients by 1.3-fold. Conclusions: The present study makes a significant contribution to the literature data because it is the first to investigate these polymorphisms.