High rate of aneuploidy in luteinized granulosa cells obtained from follicular fluid in women who underwent controlled ovarian hyperstimulation

Kaleli, Semih; Yanikkaya-Demirel, Gulderen; EREL, CEMAL; Senturk, Levent; Topçuoǧlu, Ata; İREZ, TÜLAY

doi:10.1016/j.fertnstert.2005.02.040

High rate of aneuploidy in luteinized granulosa cells obtained from follicular fluid in women who underwent controlled ovarian hyperstimulation

Atıf İçin Kopyala

Kaleli S., Yanikkaya-Demirel G., EREL C. T., Senturk L. M., Topçuoǧlu A., İREZ T.

Fertility and Sterility, cilt.84, sa.3, ss.802-804, 2005 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 84 Sayı: 3
Basım Tarihi: 2005
Doi Numarası: 10.1016/j.fertnstert.2005.02.040
Dergi Adı: Fertility and Sterility
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.802-804
İstanbul Yeni Yüzyıl Üniversitesi Adresli: Evet

Özet

We performed a prospective study to detect the cell cycle changes in luteinized granulosa cells in patients undergoing controlled ovarian stimulation with GnRH analog and gonadotropin therapy. Aneuploid DNA content was observed in 37 of 70 women (52.9%), and multiple logistic regression analysis revealed that only the dose of gonadotropins used significantly predicted the ploidy status of granulosa cells, which indicates that ovarian hyperstimulation in IVF treatment might be detrimental for the DNA content of granulosa cells. ©2005 by American Society for Reproductive Medicine.