On the nature of cellular ADP-ribosyltransferase from rat liver specific for elongation factor 2

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Sayhan O., Özdemirli M., Nurten R., Bermek E.

Biochemical and Biophysical Research Communications, vol.139, no.3, pp.1210-1214, 1986 (Scopus)

• Publication Type: Article / Article
• Volume: 139 Issue: 3
• Publication Date: 1986
• Doi Number: 10.1016/s0006-291x(86)80306-0
• Journal Name: Biochemical and Biophysical Research Communications
• Journal Indexes: Scopus
• Page Numbers: pp.1210-1214
• İstanbul Yeni Yüzyıl University Affiliated: No

Abstract

A cellular ADP-ribosyltransferase, specific for elongation factor 2 (EF-2), is found in extracts from rat liver. Co-migrating with EF-2 throughout purification, this activity is, moreover, located in the protein bands corresponding to EF-2 after native or sodium dodecyl sulfate polyacrylamide gel electrophoresis. The observed activity is thus implicated to be an inherent property of EF-2. Preincubation of EF-2 with GuoPPCH2Pox inhibits endogenous, but not diphtheria toxin catalyzed ADP-ribosylation. © 1986 Academic Press, Inc.