Akademik Veri Yönetim Sistemi
Journal of Assisted Reproduction and Genetics, cilt.28, sa.12, ss.1197-1203, 2011 (SCI-Expanded)
Objective: To evaluate predictive role of day-3 serum anti-Müllerian hormone (AMH) levels and antral follicle count (AFC) in ovarian hyperstimulation syndrome (OHSS) in patients undergoing IVF/ICSI cycles. Materials and methods: Forty-one women with moderate/severe OHSS and 41 age matched women without OHSS were compared to evaluate the predictive value of certain risk factors for OHSS. AFC, and E 2, FSH, LH, AMH, inhibin-B levels measured on day 3 of the menstrual cycle before controlled ovarian hyperstimulation. Results: Mean FSH was significantly lower (p∈<∈0.0001); and mean LH, AFC and AMH were significantly higher in women with OHSS compared to women without OHSS (p∈=∈0.049, p∈<∈0.0001 and p∈<∈0.0001, respectively). There was no significant difference in inhibin B (p∈=∈0.112) and estradiol (p∈=∈0.706) between the groups. The ROC area under curve (AUC) for AMH presented the largest AUC among the listed risk factors. AMH (AUC∈=∈0.87) and AFC (AUC∈=∈0.74) had moderate accuracy for predicting OHSS while Inhibin B (AUC∈=∈0.58) and LH (AUC∈=∈0.61) had low accuracy. The cut-off value for AMH 3.3 ng/mL provided the highest sensitivity (90%) and specificity (71%) for predicting OHSS. It's positive (PPV) and negative predictive values (NPV) were 61% and 94%, respectively. The cut-off value for AFC was 8 with 78% sensitivity, 65% specificity, 52% PPV and 86% NPV. Conclusion: Measurement of basal serum AMH and AFC can be used to determine the women with high risk for OHSS. © 2011 Springer Science+Business Media, LLC.