Increased lipoperoxide levels and antioxidant system in colorectal cancer

Özdemirler G., Pabuççuoǧlu H., Bulut T., Buǧra D., Uysal M., Toker G.

Journal of Cancer Research and Clinical Oncology, cilt.124, sa.10, ss.555-559, 1998 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 124 Sayı: 10
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1007/s004320050214
  • Dergi Adı: Journal of Cancer Research and Clinical Oncology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.555-559
  • Anahtar Kelimeler: γ-Glutamyl transpeptidase, γ-Glutamylcysteine synthetase, Colorectal cancer, Drug resistance, Glutathione, Glutathione peroxidase, Glutathione S- transferase, Lipid peroxides, Superoxide dismutase
  • İstanbul Yeni Yüzyıl Üniversitesi Adresli: Hayır

Özet

In this study, lipid peroxide and glutathione (GSH) levels, GSH peroxidase, GSH S-transferase, superoxide dismutase, γ-glutamylcysteine synthetase and γ-glutamyl transpeptidase activities were investigated in tumorous and nontumorous colorectal tissues obtained from tell patients diagnosed with colon and rectum cancer. Histopathological evaluations, including type, stage, necrosis and lymphocyte infiltration, were also performed for each patient. According to the results, lipid peroxide and GSH levels and the activities of GSH peroxidase, superoxide dismutase, γ- glutamylcysteine synthetase were found to be increased, while GSH S- transferase and γ-glutamyl transpeptidase activities remained unchanged in tumors compared to adjacent normal tissues of subjects with colorectal cancer. However, the considerable interindividual variations were found in these parameters. A definite interrelation between histopathological results with lipid peroxidation and antioxidant system was not observed.