Simultaneous determination of acetaminophen and phenobarbital in suppositories by partial least-squares spectrophotometric calibration

BOZDOĞAN A. E., KANDEMİR G., ACAR A. M.

Analytical Letters, vol.25, no.11, pp.2051-2058, 1992 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 11
  • Publication Date: 1992
  • Doi Number: 10.1080/00032719208020074
  • Journal Name: Analytical Letters
  • Journal Indexes: Scopus
  • Page Numbers: pp.2051-2058
  • Keywords: acetaminophen, Partial least-squares calibration, pharmaceutical formulations, phenobarbital, simultaneous determination, UV spectrophotometry
  • İstanbul Yeni Yüzyıl University Affiliated: Yes

Abstract

The use of partial least-squares spectrophotometric calibration for the simultaneous determination of suppositories in a multicomponent formulation is presented. This method is applied to the determination of acetaminophen and phenobarbital in suppository preparations. The results show that these components in a molar ratio of about 61:1 in suppositories have been determined simultaneously with high precision. © 1992, Taylor & Francis Group, LLC. All rights reserved.