Akademik Veri Yönetim Sistemi
Acta Pharmaceutica Sciencia, cilt.52, sa.1, ss.5-18, 2010 (Scopus)
The aim of this study was to evaluate ciprofloxacin hydrochloride-loaded chitosan microspheres for nasal administration. Microspheres were prepared by spray drying method and evaluated with respect to the particle size, morphological properties, drug-polymer interaction, production yield, drug content, encapsulation efficiency, in vitro drug release and kinetic assessment and in vivo bioavailability. The particle size of microspheres prepared ranged from 3.3 to 6.7 μm. The microspheres showed spherical shape and smooth surface. For all formulations, drug loading capacity and microsphere yield were higher than 74% and 38%, respectively. Based on in vitro evaluation of microspheres, the most suitable formulation has chosen for in vivo nasal application to rats. In vivo studies showed that, absolute bioavailability of CIPRO formulations (oral solution, nasal solution and nasal microsphere suspension) were found as 8.57%, 15.7% and 32.9%, respectively. According to the obtained data, CIPRO-loaded chitosan microspheres prepared with spray-drying method are able to prove sustained release and could be use via nasal route as an alternative to oral route.