The hepatic lipid peroxidation, copper and fibrosis in cholestatic rats

Aykac G., Özdemirler G., Alptekin N., Arican N., Oz B., Uysal M., ...Daha Fazla

Pharmacological Research, cilt.21, sa.6, ss.701-706, 1989 (Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 6
  • Basım Tarihi: 1989
  • Doi Numarası: 10.1016/1043-6618(89)90229-6
  • Dergi Adı: Pharmacological Research
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.701-706
  • Anahtar Kelimeler: cholestasis, copper, fibrosis, lipid peroxidation
  • İstanbul Yeni Yüzyıl Üniversitesi Adresli: Hayır

Özet

Hepatic lipid peroxidation was shown to be stimulated in the livers of cholestatic rats with increased hydroxyproline levels. In another group, cholestatic rats were fed with a copper-supplemented diet to increase hepatic copper levels. Although liver copper concentrations increased about 16-fold in copper supplemented cholestatic rats compared to normally fed cholestatic rats, no change was observed either in hepatic lipid peroxidation or in hydroxyproline levels. © 1989.