The hepatic lipid peroxidation, copper and fibrosis in cholestatic rats

Aykac G., Özdemirler G., Alptekin N., Arican N., Oz B., Uysal M., ...More

Pharmacological Research, vol.21, no.6, pp.701-706, 1989 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 6
  • Publication Date: 1989
  • Doi Number: 10.1016/1043-6618(89)90229-6
  • Journal Name: Pharmacological Research
  • Journal Indexes: Scopus
  • Page Numbers: pp.701-706
  • Keywords: cholestasis, copper, fibrosis, lipid peroxidation
  • İstanbul Yeni Yüzyıl University Affiliated: No

Abstract

Hepatic lipid peroxidation was shown to be stimulated in the livers of cholestatic rats with increased hydroxyproline levels. In another group, cholestatic rats were fed with a copper-supplemented diet to increase hepatic copper levels. Although liver copper concentrations increased about 16-fold in copper supplemented cholestatic rats compared to normally fed cholestatic rats, no change was observed either in hepatic lipid peroxidation or in hydroxyproline levels. © 1989.