Research Information System
Jinekoloji ve Obstetrik Dergisi, vol.14, no.4, pp.249-253, 2000 (Scopus)
OBJECTIVE: The aim of this study is to evaluate the importance of day three E2, FSH, LH levels in determination of oocyte number in short-protocol GnRHa stimulated cycles. STUDY DESIGN: In this prospective study Gn-RH analogue was started on day one for controlled ovarian hyperstimulation (COH) in 223 cases and day three E2, LH and FSH levels were determined. The relation among the age of patient, hormones levels in natural cycle and day three hormones levels in COH cycle, characteristics of ovulation cycle, oocyte number and embryo number was evaluated with Pearson correlation test. We determined the FSH cut-off level determining inappropriate response based on day three FSH level in COH with ROC analysis. RESULTS: There was an inverse statìstically signìficant relationship between oocyte number and the age of patient (r=0.3, p<0.01), also between oocyte number and basal FSH level in natural cycle (r=-0.28, p<0.01) and also between oocyte number and day three FSH level in COH (r=-0.44, p<0.001). The most sìgnificant variable affecting oocyte number was day three FSH level in COH. Day three FSH cut-off level in COH determining three or more oocytes was found with ROC analysis as 9.5 mlU/mL. CONCLUSION: It was found that day three FSH level in stimulated cycle was more important than patient age and basal FSH in determining response to COH.