Male infertility in Sertoli cell-only syndrome: An investigation of autosomal gene defects
International Journal of Urology, cilt.26, sa.2, ss.292-298, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 26 Sayı: 2
- Basım Tarihi: 2019
- Doi Numarası: 10.1111/iju.13863
- Dergi Adı: International Journal of Urology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.292-298
- Anahtar Kelimeler: array comparative genomic hybridization, infertility, Sertoli cell-only syndrome
- İstanbul Yeni Yüzyıl Üniversitesi Adresli: Evet
Özet
Objectives: To detect autosomal genetic defects and to determine candidate genes in Sertoli cell-only syndrome infertile men. Methods: Single-nucleotide polymorphism + comparative genomic hybridization microarray technology was carried out on 39 Sertoli cell-only syndrome infertile patients in the present study. Array comparative genomic hybridization compares the patient's genome against a reference genome, and identifies uncover deletions, amplifications and loss of heterozygosity. Results: A link between defective spermatogenesis genes and infertility was examined, and amplifications and deletions in several genes were detected, including homeobox gene; synaptonemal complex element protein 1; collagen, type I, alpha 1; imprinted maternally expressed transcript; and potassium voltage-gated channel subfamily Q member 1. Conclusions: The present data suggest that several genes can play an important role in spermatogenesis and progression of Sertoli cell-only syndrome.