Akademik Veri Yönetim Sistemi
İstanbul Kuzey Klinikleri, cilt.5, sa.4, ss.323-328, 2018 (Hakemli Dergi)
OBJECTIVE: Uncontrolled inflammatory responses could contribute to the pathogenesis of many leading causes of humanmorbidity and mortality. Aspirin is an anti-inflammatory and antithrombotic drug that is used in the primary and secondaryprotection in atherothrombotic diseases and complications. The aim of the present study was to analyze the effect of aspirinresistance on the extent and severity of atherosclerosis.METHODS: One hundred patients who underwent coronary angiography with suspected or known coronary artery diseaseand were using aspirin were enrolled in the study.RESULTS: Of these 100 patients, 30 (8 female and 22 male) formed the aspirin-resistant group (ARG), and 70 (22 femaleand 48 male) formed the control group. Gensini scoring system (GSS) was significantly higher in the ARG than in the controlgroup (80.5 (36–166) vs. 45 (2–209); p<0.001). The number of percutaneous coronary intervention (PCI) patients wassignificantly higher in the ARG (13 of 30 (43.3%) ARG vs. 13 of 70 (18.6%) control group; p=0.01). Furthermore, whenwe evaluate the 16 reintervention patients, stent restenosis was significantly higher in the ARG (11 of 16 (68.75%) ARG vs.5 of 16 (31.25%) control group; p=0.016). Multivariate logistic regression analysis revealed that GSS (p=0.038; 95% CI:1.001–1.026) and PCI history (p=0.017; 95% CI: 1.182–89.804) were independent risk factors for aspirin resistance.CONCLUSION: In conclusion, atherosclerotic burden as calculated by the GSS is significantly higher in aspirin-resistantpatients. According to this result, we suggest that aspirin treatment can be prescribed in higher doses in aspirin resistancepatients with coronary events. Furthermore, GSS and PCI history could be independent predictors of aspirin resistance.