A novel screening test for colon cancer: Talin-1

Bostanci O., Kemik O., Kemik A., Battal M., Demir U., Purisa S., ...Daha Fazla

European Review for Medical and Pharmacological Sciences, cilt.18, sa.17, ss.2533-2537, 2014 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 17
  • Basım Tarihi: 2014
  • Dergi Adı: European Review for Medical and Pharmacological Sciences
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2533-2537
  • Anahtar Kelimeler: Adhesion, Angiogenesis, Colon cancer, Talin-1
  • İstanbul Yeni Yüzyıl Üniversitesi Adresli: Hayır

Özet

OBJECTIVE: Cell adhesion and angiogenesis within the extracellular matrix involve special signaling molecules, such as inte-grins and the actin binding protein Talin-1. The aim of this study was to investigate and describe the expression of Talin-1 for the early detection of colon cancer. PATIENTS AND METHODS: Blood serum samples were collected from 50 healthy volunteers and from 90 patients with colon cancer. Using an enzyme-linked immunosorbent assay (ELISA), all 140 samples were analyzed. RESULTS: Preoperative levels of Talin-1 in the serum were significantly higher in patients with colon cancer (p < 0.001). No significant correlation was found between preoperative levels of Talin-1 in the serum and the age and gender of the patients (p < 0.05). However, a significant correlation was found between Talin-1 levels and the tumor grade, TNM stage, and lymph node metastasis (p < 0.001). CONCLUSIONS: Talin-1 may play a role in the reinforcement of cell proliferation, cell adhesion, and angiogenesis in colon cancer. Thus, the Talin-1 protein activity may be a novel bio-marker to detect colon cancer in humans.