Effect of different kefir dosages on inflammation status, metabolic profile, and anthropometric measurements in adults: A systematic review and meta-analysis

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Hamsho M., Hawari R., Yeşil Z., Dakhel Z., DURSUN SAYDAM D., TERZİ M., ...Daha Fazla

Nutrition, Metabolism and Cardiovascular Diseases, 2025 (SCI-Expanded)

• Yayın Türü: Makale / Derleme
• Basım Tarihi: 2025
• Doi Numarası: 10.1016/j.numecd.2025.104364
• Dergi Adı: Nutrition, Metabolism and Cardiovascular Diseases
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, CINAHL, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
• Anahtar Kelimeler: Anthropometric measurements, Gut microbiota, Inflammation status, Kefir, Meta-analysis, Metabolic profile
• İstanbul Yeni Yüzyıl Üniversitesi Adresli: Evet

Özet

Aim: Kefir, a traditional fermented milk, is rich in probiotics including, lactic acid producing bacteria and yeasts which act as fermentation starters. Studies have suggested its metabolic health benefits, though findings remain inconsistent. This systematic review and meta-analysis evaluated the effects of kefir consumption on anthropometric measures, metabolic profile, and inflammation. Data synthesis: A comprehensive literature search across Scopus, Embase, and PubMed (up to 25-01, 2025) identified 24 relevant interventional studies from 702 articles. Mean ± SD values were obtained for both intervention and control groups. Forest plots and sub-group analyses by kefir dosage were generated using Cochrane Program Review Manager version 5.4. Conclusion: Kefir consumption induced a significant reduction of fasting blood glucose (MD= −8.46 mg/dL, p = 0.006), and HOMA-IR (MD= −1.71, p = 0.004). However, no significant effects were observed on anthropometric measures, lipid profile, or inflammatory markers. In conclusion, regular kefir consumption may improve blood glucose and insulin sensitivity, but further research is needed for definitive recommendations.