The effect of propofol (anesthetic and inhibitor of CYP3A4) on serum lidocaine concentrations in smokers and chronic alcohol consumers

Elmas T., Mavioglu O., Oztekin S., Elar Z., GÜVEN H.

International Journal of Clinical Pharmacology and Therapeutics, cilt.41, sa.4, ss.182-184, 2003 (SCI-Expanded, Scopus)

Özet

In summary, it is known that CYP3A4 and CYP1A2 isoenzymes are involved in lidocaine metabolism, and these isoenzymes were inhibited by propofol and induced by chronic cigarette-alcohol consumption. We observed that the administration of a single dose of propofol and chronic cigarette-alcohol consumption has no effect on serum lidocaine concentrations. The results of Hamaoka et al. [1999] are not directly comparable to our study, because they administered propofol as a single i.v. bolus and then infusion was started and maintained for 1 hour. We administered only one single dose of propofol to the patients. Since propofol has a very short duration of action, single administration of propofol is not sufficient to produce enzyme inhibition. However it is considered that, lidocaine metabolism can be affected by prolonged i.v. infusion of propofol.