Astaxanthin-Mediated Returning the Aquaporin-1 to Basal Level May be an Alternative Treatment Approach in Radiotherapy-Induced Lung Injury

Se A., Y E., He C., Hı B., H A., Hasseyid N., ...Daha Fazla

FORTUNE, cilt.08, sa.02, ss.135-142, 2024 (Hakemli Dergi)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 08 Sayı: 02
  • Basım Tarihi: 2024
  • Doi Numarası: 10.26502/jcsct.5079234
  • Dergi Adı: FORTUNE
  • Derginin Tarandığı İndeksler: Periodicals Index Online, ABI/INFORM, AgeLine, Applied Science & Technology Source, Art Source, ATLA Religion Database, Business Source Elite, Business Source Premier, EBSCO Education Source, MLA - Modern Language Association Database, PAIS International, Public Affairs Index
  • Sayfa Sayıları: ss.135-142
  • İstanbul Yeni Yüzyıl Üniversitesi Adresli: Evet

Özet

Astaxanthin-Mediated Returning the Aquaporin-1 to Basal Level May be an Alternative Treatment Approach in Radiotherapy-Induced Lung Injury

Background: Radiotherapy (12-RAD), which has an important place in cancer treatment, destroys cancer cells, but also negatively affects healthy tissues in that area. Astaxanthin (ATX) is known to have powerful antioxidant, anti-inflammatory and antiapoptotic properties. In this study, we aimed to evaluate the effects of ATX on lung injury after radiotherapy. Methods and Results: 32 rats were divided into 4 groups as control, 12- RAD (a single dose of 10 Gy x-ray was given at a rate of 0.62 Gy/min), 12-RAD+ATX, + ATX (10mg/kg ATX was administered by oral gavage for 7 days). Twenty-four hours after the last ATX application, the lung tissues of the rats were taken for biochemical, genetic, histopathological, and immunohistochemical examinations. 12-RAD increased the oxidative stress markers TOS, OSI levels, the expression of VCAM-1, VEGF-A, which increases in inflammation, and the apoptotic marker, caspase-3. It also significantly reduced Aquaporin-1 and TAS levels. On the other hand, ATX has returned all these parameters.

Conclusion: All evidence suggests that the use of ATX may be a potential therapeutic agent against radiotherapy-induced lung injury.