Liver lipid peroxidation and glutathione‐related defence enzyme systems in mice treated with paracetamol

Özdemirler G., Aykaç G., Uysal M., Öz H.

Journal of Applied Toxicology, cilt.14, sa.4, ss.297-299, 1994 (Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 4
  • Basım Tarihi: 1994
  • Doi Numarası: 10.1002/jat.2550140410
  • Dergi Adı: Journal of Applied Toxicology
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.297-299
  • Anahtar Kelimeler: glutathione peroxidase (GSH‐Px), glutathione S‐transferase (GST), lipid peroxidation, mouse liver, paracetamol
  • İstanbul Yeni Yüzyıl Üniversitesi Adresli: Hayır

Özet

Glutathione levels were found to be decreased while lipid peroxide levels were increased in total liver homogenates 6 h following paracetamol treatment (500 mg kg−1 i.p.). Furthermore, it has been determined that cytosolic glutathione S‐transferase (GST) activity was decreased and glutathione peroxidase (GSH‐Px) activity remained unchanged. On the other hand, a decrease in liver microsomal lipid peroxide levels and an increase in GST and GSH‐Px activity has been observed. We concluded that decreased lipid peroxide levels in microsomes could be a consequence of increased GSH‐Px and GST enzyme activities. In this way, these glutathione‐related defence enzyme systems may play an important role in protecting microsomes from lipid peroxidation. Copyright © 1994 John Wiley & Sons, Ltd.