Influence of serotonin on the human ureter: An in vitro pharmacological study

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Gidener S., Kirkali Z., GÜVEN H.

Urologia Internationalis, cilt.55, sa.4, ss.202-204, 1995 (Scopus)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 55 Sayı: 4
• Basım Tarihi: 1995
• Doi Numarası: 10.1159/000282786
• Dergi Adı: Urologia Internationalis
• Derginin Tarandığı İndeksler: Scopus
• Sayfa Sayıları: ss.202-204
• Anahtar Kelimeler: 5-Hydroxytryptamine receptors, Human, Serotonin, Smooth muscle, Ureter
• İstanbul Yeni Yüzyıl Üniversitesi Adresli: Hayır

Özet

The influence of serotonin (5-hydroxytryptamine, 5-HT) on human ureteral smooth muscle was explored in a series of in vitro experiments. 5-HT evoked a dose-dependent contraction of the ureter. The effect of 5-HT was unaltered by blockade of 5HT3 and 5HT4 receptors and muscarinic cholinergic receptors. The 5HT2 receptor antagonist ketanserin (KT; 10^––5–10^––4M) and mixed 5HT1/5HT2 receptor antagonist methysergide (MS; 5 × 10^––5M) inhibited the effect of 5-HT. Since the antagonist dissociation constant at 5HT2 receptors for both KT and MS is found to be approximately 10^––9M, it is concluded that this contractile effect may have been mediated by some other, as yet uncharac-terized 5-HT receptor. We believe that 5-HT is a potential neurotransmitter in the human upper ureteral smooth muscle. © 1995 S. Karger AG, Basel.