Efficacy of 7-day treatment with metronidazole+miconazole (Neo-Penotran®) - A triple-active pessary for the treatment of single and mixed vaginal infections


Ozyurt E., Toykuliyeva M., Danilyans I., Morton O., BAKTIR G.

International Journal of Gynecology and Obstetrics, cilt.74, sa.1, ss.35-43, 2001 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 74 Sayı: 1
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1016/s0020-7292(01)00388-5
  • Dergi Adı: International Journal of Gynecology and Obstetrics
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.35-43
  • Anahtar Kelimeler: Bacterial vaginosis, Metronidazole, Miconazole, Mixed vaginal infections, Trichomonal vaginitis, Vulvovaginal candidiasis
  • İstanbul Yeni Yüzyıl Üniversitesi Adresli: Evet

Özet

Objective: To evaluate the efficacy of Neo-Penotran® pessaries (metronidazole 500 mg+miconazole nitrate 100 mg) in candidal, bacterial and trichomonal vaginitis and in mixed vaginal infections. Method: Ninety-seven patients with clinical diagnosis of vaginitis entered this open, non-comparative study. Each patient inserted one pessary twice daily for 7 days. Gynecological and microbiological assessments were carried out before, and 8-10/21-23 days after the start of treatment. Results: Vaginitis symptoms were resolved in 91% of the 74 patients evaluated, and improved in a further 7%. Microbiological cure rates were 97.3% for trichomonal, 86.6% for bacterial and 81% for candidal vaginitis. Recurrence rates were 2.7, 3.8 and 16.1%, respectively. Overall microbiological cure rate for mixed infections was 86%, with 93% for trichomonal+bacterial, and 73% for bacterial+candidal vaginitis. In two out of three cases with trichomonal+bacterial+candidal infection, the microorganisms were eradicated completely. Conclusion: Neo-Penotran® provides immediate and effective treatment for vaginitis, irrespective of single or multiple infection, even when the diagnosis may be uncertain. Copyright © 2001 International Federation of Gynecology and Obstetrics.