Protective effect of Nigella sativa oil against binge ethanol-induced oxidative stress and liver injury in rats

Develi S., Evran B., Betül Kalaz E., Koçak-Toker N., ÖZDEMİRLER G.

Chinese Journal of Natural Medicines, vol.12, no.7, pp.495-499, 2014 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 7
  • Publication Date: 2014
  • Doi Number: 10.1016/s1875-5364(14)60077-7
  • Journal Name: Chinese Journal of Natural Medicines
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.495-499
  • Keywords: Binge ethanol, Liver, Nigella sativa, Oxidative stress, Rats
  • İstanbul Yeni Yüzyıl University Affiliated: No

Abstract

Aim: Nigella sativa L. (Ranunculaceae) is considered as a therapeutic plant-based medicine for liver damage. In this study, the aim was to study the effect of Nigella sativa oil (NSO) pretreatment on ethanol-induced hepatotoxicity in rats. Method: Rats were given Nigella sativa oil at doses of 2.5 and 5.0 mL·kg-1, orally for 3 weeks, followed by oral ethanol (EtOH) administration (5 g·kg-1) every 12 h three times (binge model). Results: Binge ethanol application caused significant increases in plasma transaminase activities and hepatic triglyceride and malondialdehyde (MDA) levels. It decreased hepatic glutathione (GSH) levels, but did not change vitamins E and vitamin C levels and antioxidant enzyme activities. NSO (5.0 mL·kg-1) pretreatment significantly decreased plasma transaminase activities, hepatic MDA, and triglyceride levels together with amelioration in hepatic histopathological findings. Conclusion: NSO pretreatment may be effective in protecting oxidative stress-induced hepatotoxicity after ethanol administration. © 2014 China Pharmaceutical University.