Determination of Ternary mixtures of dextromethorphan hydrobromide, pseudoephedrine hydrochloride and triprolidine hydrochloride in syrups by partial least-squares multivariate calibration

Dönmez Ö. A., Bozdoǧan A., KANDEMİR G.

Reviews in Analytical Chemistry, cilt.26, sa.3, ss.209-218, 2007 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 3
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1515/revac.2007.26.3.209
  • Dergi Adı: Reviews in Analytical Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.209-218
  • Anahtar Kelimeler: Dextromethorphan hydrobromide, Multivariate calibration, Pseudoephedrine hydrochloride, Triprolidine hydrochloride
  • İstanbul Yeni Yüzyıl Üniversitesi Adresli: Evet

Özet

PLS-2, a partial least-squares multivariate calibration, was used for the determination of dextromethorphan hydrobromide (DEX), pseudoephedrine hydrochloride (PSE) and triprolidine hydrochloride (TRP) in syrup samples. The method allows the simultaneous quantification of the analytes that the closely overlapping spectral bands are not efficiently solved. The calibration set consisting of 27 samples with 60, 80, 100 μg mL-1 of DEX, 180, 240, 300 μg mL-1 of PSE and 8,10,12 μg mL-1 of TRP was used for calibration matrix. The absorbances were recorded between 230 and 320 nm every 5 nm. The accuracy and precision of the method have been determined and the method has been validated by synthetic mixtures.