Akademik Veri Yönetim Sistemi
Turkiye Klinikleri Journal of Medical Sciences, cilt.38, sa.4, ss.340-347, 2018 (Scopus)
Objective: The breast and the thyroid gland are hormone responsive organs that are closely related with each other. An association among thyroid disorders, Vitamin D (VitD) deficiency and breast cancer (BC) risk has been suggested, although the results are inconclusive. We aimed to investigate relationship between BC and thyroid hormones (TH) levels, thyroid antibodies and VitD levels. Material and Methods: We included BC women (Group II, n=90) with newly diagnosed and healthy control group (Group I, n=90) in our study. The patients were newly diagnosed breast cancer and did not yet received neoadjuvant therapy. In sera of these patients and control group, free T3 (FT3), free T4 (FT4), thyroid stimulating hormone (TSH), anti-thyroid peroxidase (A-TPO), anti-thyroglobulin (A-TG), thyroglobulin, CA-15.3 and VitD levels were measured by electrochemiluminescence method using a cobas e 601 immunoassay device (Roche Diagnostic, USA). Results: According to our results, when we compared with Group I and Group II each other, we found that serum A-TG levels of patients with Group II were statistically higher than Group I and VitD levels were statistically low. However, we did not find statistically difference among FT3, FT4, TSH, A-TPO, TG and CA-15.3. Conclusion: Considering thyroid antibody positivity and VitD insufficiency, post-menopausal women can be followed for breast cancer and advantage for early diagnosis of cancer. However, extensive prospective studies are needed to determine whe ther thyroid antibodies and VitD levels are potential prognostic markers for breast cancer patients.